Chan P C, Wei D C, Tam S C, Chan F L, Yeung W C, Cheng I K
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Nephrol Dial Transplant. 1992;7(2):137-42. doi: 10.1093/oxfordjournals.ndt.a092084.
Seventeen patients with post-renal transplant erythrocytosis and 17 non-erythrocytotic controls, matched in age, sex, serum creatinine and source of donor kidney, were studied to determine the role of erythropoietin, male sex hormones (testosterone, FSH, LH), and various patient risk factors in post-transplant erythrocytosis. Serum erythropoietin was significantly greater in erythrocytotic patients (35.6 +/- 5.7 mU/ml) than non-erythrocytotic patients (18.8 +/- 2.6 mU/ml) (P less than 0.05) and normal subjects (22.5 +/- 0.95 mU/ml) P less than 0.05). Serum testosterone was similar between the male study (13.2 +/- 6.2 nmol/l) and control (13.1 +/- 6.0 nmol/l) patients. This might be due to the greater basal LH in the male control subjects (13.9 +/- 11.7 IU/l versus 8.0 +/- 3.3 IU/l in erythrocytotic males, P = 0.084). Basal FSH in the male controls was greater than that in the study group (13.7 +/- 14 IU/l versus 6.8 +/- 2.9 IU/l, P = 0.067). Among the demographic risk factors, only the smoking history was important. There were more smokers among the erythrocytotic patients than controls (P = 0.051).
对17例肾移植后红细胞增多症患者和17例年龄、性别、血清肌酐及供肾来源相匹配的非红细胞增多症对照者进行了研究，以确定促红细胞生成素、男性性激素（睾酮、促卵泡激素、促黄体生成素）及各种患者风险因素在移植后红细胞增多症中的作用。红细胞增多症患者的血清促红细胞生成素（35.6±5.7 mU/ml）显著高于非红细胞增多症患者（18.8±2.6 mU/ml）（P<0.05）和正常受试者（22.5±0.95 mU/ml）（P<0.05）。男性研究组（13.2±6.2 nmol/l）和对照组（13.1±6.0 nmol/l）患者的血清睾酮相似。这可能是由于男性对照受试者的基础促黄体生成素较高（13.9±11.7 IU/l，红细胞增多症男性为8.0±3.3 IU/l，P = 0.084）。男性对照组的基础促卵泡激素高于研究组（13.7±14 IU/l对6.8±2.9 IU/l，P = 0.067）。在人口统计学风险因素中，只有吸烟史具有重要意义。红细胞增多症患者中的吸烟者多于对照组（P = 0.051）。
