Department of Medical Chemistry, Radium Hospital, Oslo University Hospital, Fürst Medical Laboratory and IKE/Clinical Chemistry, Linköping University, Sweden.
Scand J Clin Lab Invest. 2009;69(8):873-9.e1-11. doi: 10.3109/00365510903380886.
Reference intervals were calculated for male testosterone, SHBG, FSH and LH in serum from 599 individuals in the NORIP study. At 30 years of age, reference limits were calculated to 10.4-32.6 nmol/L testosterone, 13.5-57.4 nmol/L SHBG, 1.93-9.7 IU/L LH and 1.5-10.3 IU/L FSH, at 50 years, 9.3-31.3 nmol/L (testosterone), 18.4-75.6 nmol/L (SHBG), 2.01-10.4 IU/L (LH) and 2.04-12.4 IU/L (FSH), and at 70 years 8.6 to 30.7 nmol/L (testosterone), 27.8-101 nmol/L (SHBG), 2.22-11.2 IU/L (LH) and 2.71-14.2 IU/L (FSH). All age-+related changes were statistically significant. Reference intervals were also calculated for indices derived from testosterone, SHBG and albumin. Free androgen index, simply the ratio between testosterone and SHBG, returned results differing from the other elaborate indices, and the study thus favors use of a more elaborate index such as calculated free testosterone (CFT).
在 NORIP 研究中，对 599 名男性的血清睾酮、SHBG、FSH 和 LH 进行了参考区间计算。在 30 岁时，计算出的参考范围为 10.4-32.6 nmol/L 的睾酮、13.5-57.4 nmol/L 的 SHBG、1.93-9.7 IU/L 的 LH 和 1.5-10.3 IU/L 的 FSH；在 50 岁时，参考范围为 9.3-31.3 nmol/L（睾酮）、18.4-75.6 nmol/L（SHBG）、2.01-10.4 IU/L（LH）和 2.04-12.4 IU/L（FSH）；在 70 岁时，参考范围为 8.6 至 30.7 nmol/L（睾酮）、27.8-101 nmol/L（SHBG）、2.22-11.2 IU/L（LH）和 2.71-14.2 IU/L（FSH）。所有与年龄相关的变化均具有统计学意义。还计算了从睾酮、SHBG 和白蛋白衍生的指数的参考区间。游离雄激素指数（即睾酮与 SHBG 的比值）的结果与其他复杂指数不同，因此该研究更倾向于使用更复杂的指数，如计算游离睾酮（CFT）。
