Gallais V, Lacour J P, Perrin C, Ghanem G, Bodokh I, Ortonne J P
Department of Dermatology, University of Nice, Hôpital Pasteur, France.
Br J Dermatol. 1992 Apr;126(4):387-91. doi: 10.1111/j.1365-2133.1992.tb00686.x.
Two patients with AIDS are described who developed acral hyperpigmented macules of the fingers, palms and soles, buccal mucosa and genitalia, associated with longitudinal melanonychia. These pigmentary changes seemed to be independent of zidovudine and were associated in one with diffuse melanoderma and elevated levels of alpha-MSH. Histological and ultrastructural studies showed an increase of the dendrites and pigmentation of the melanocytes and few melanosomes in the keratinocytes.
描述了两名艾滋病患者，他们的手指、手掌、脚底、颊黏膜和生殖器出现了肢端色素沉着性斑疹，并伴有甲纵嵴黑甲。这些色素沉着变化似乎与齐多夫定无关，其中一名患者还伴有弥漫性黑皮病和α-促黑素水平升高。组织学和超微结构研究显示，黑素细胞的树突增多、色素沉着，角质形成细胞中的黑素小体较少。
