Britton K T, McLeod S, Koob G F, Hauger R
Department of Psychiatry, San Diego VAMC, CA 92161.
Pharmacol Biochem Behav. 1992 Feb;41(2):399-403. doi: 10.1016/0091-3057(92)90117-x.
The 3 alpha-hydroxy A-ring-reduced steroid alphaxalone was examined for its ability to block stress-induced behavioral effects. Alphaxalone (3 and 6 mg/kg, IP) significantly antagonized the response-suppressing effects of corticotropin releasing factor (CRF) (0.5 micrograms, ICV) on punished responding in a conflict paradigm. In the plus maze, alphaxalone (3 and 6 mg/kg, IP) blocked the anxiogenic behavioral effects produced by a prior ambient-temperature swim stress. These doses of alphaxalone produced no intrinsic effects on plasma ACTH levels, nor did they attenuate CRF-induced increases in plasma ACTH. These findings support the hypothesis that some pregnane steroids may be involved in the modulation of an animal's behavioral response to stress and suggest that these effects may occur independently of the hypothalamic-pituitary-adrenocortical axis.
研究了3α-羟基A环还原甾体阿法沙龙阻断应激诱导行为效应的能力。阿法沙龙（3和6毫克/千克，腹腔注射）显著拮抗促肾上腺皮质激素释放因子（CRF）（0.5微克，脑室内注射）在冲突范式中对惩罚反应的反应抑制作用。在十字迷宫中，阿法沙龙（3和6毫克/千克，腹腔注射）阻断了先前环境温度游泳应激产生的致焦虑行为效应。这些剂量的阿法沙龙对血浆促肾上腺皮质激素（ACTH）水平无内在影响，也未减弱CRF诱导的血浆ACTH升高。这些发现支持了以下假设：一些孕烷甾体可能参与调节动物对应激的行为反应，并表明这些效应可能独立于下丘脑-垂体-肾上腺皮质轴发生。
