Martinez J A, Fargeas M J, Bueno L
Department of Physiology and Pharmacology, Faculty of Medicine, Espinardo, Murcia, Spain.
Pharmacol Biochem Behav. 1992 Feb;41(2):461-4. doi: 10.1016/0091-3057(92)90127-2.
This work was performed to compare withdrawal symptoms induced by the administration of the central vs. peripheral benzodiazepine antagonists in rats treated chronically with diazepam (15 mg/kg, SC) for 8 days. Withdrawal was expressed as motor, autonomic, and behavioral signs. Significant withdrawal occurred after the administration of both flumazenil (15 and 20 mg/kg, IP) and PK11195 (5 and 10 mg/kg, IP). With these doses, PK11195 induced diarrhea and decreased motor activity more than did flumazenil. These preliminary results suggest that peripheral benzodiazepine receptors are involved in the withdrawal syndrome in diazepam-dependent rats.
本研究旨在比较中枢性与外周性苯二氮䓬拮抗剂对长期（8天）皮下注射地西泮（15mg/kg）的大鼠产生的戒断症状。戒断症状表现为运动、自主神经和行为体征。腹腔注射氟马西尼（15和20mg/kg）和PK11195（5和10mg/kg）后均出现明显戒断症状。在此剂量下，PK11195比氟马西尼更易引起腹泻并降低运动活性。这些初步结果表明外周苯二氮䓬受体参与了地西泮依赖大鼠的戒断综合征。
