Isbister W H
Department of Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Aust N Z J Surg. 1992 May;62(5):350-3. doi: 10.1111/j.1445-2197.1992.tb07202.x.
New Zealand (NZ) has a high risk population for the development of large bowel cancer (LBC). The Kingdom of Saudi Arabia (KSA) has a low risk population and is estimated to have incidence and mortality rates which are ten times lower than NZ. It has already been shown that in NZ, females have a higher incidence of right-sided colonic cancer and males a higher incidence of rectal cancer. To determine whether the same situation exists in a low risk population the NZ data were compared with similar data from the cancer registry at the King Faisal Specialist Hospital and Research Center (KFSHRC). Between 1975 and 1989, 433 Saudi and Yemeni patients with LBC were registered at KPSH. The subsite distribution of tumours in this group were compared with the subsite distribution in 4678 patients registered in NZ between 1972 and 1975. The male to female (M:F) ratio for right-sided tumours in KSA was 1:0.90 compared with 1:1.56 in NZ whereas the ratios for rectal tumours were 1:0.61 and 1:0.83 respectively. This study confirms the presence of a lower frequency of right-sided tumours in females in a low risk country and further confirms the importance of gender in LBC. It may be that early and multiple child bearing, physical activity and relatively poor diets have been protective for Saudi females.
新西兰（NZ）是患大肠癌（LBC）的高危人群。沙特阿拉伯王国（KSA）是低危人群，据估计其发病率和死亡率比新西兰低十倍。研究表明，在新西兰，女性右侧结肠癌发病率较高，男性直肠癌发病率较高。为了确定在低危人群中是否存在同样的情况，将新西兰的数据与法赫德国王专科医院和研究中心（KFSHRC）癌症登记处的类似数据进行了比较。1975年至1989年期间，有433名沙特和也门LBC患者在KPSH登记。将该组肿瘤的亚部位分布与1972年至1975年期间在新西兰登记的4678名患者的亚部位分布进行了比较。沙特阿拉伯右侧肿瘤的男女比例（M:F）为1:0.90，而新西兰为1:1.56，而直肠癌的比例分别为1:0.61和1:0.83。这项研究证实了在低危国家女性右侧肿瘤的发生率较低，并进一步证实了性别在LBC中的重要性。可能是早期多次生育、体育活动和相对较差的饮食对沙特女性起到了保护作用。
