类风湿关节炎合并中性粒细胞减少症患者中与T细胞受体β链基因重排相关的淋巴细胞亚群。
Lymphocyte subsets associated with T cell receptor beta-chain gene rearrangement in patients with rheumatoid arthritis and neutropenia.
作者信息
Gonzales-Chambers R, Przepiorka D, Winkelstein A, Agarwal A, Starz T W, Kline W E, Hawk H
机构信息
Montefiore University Hospital, Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, PA 15213.
出版信息
Arthritis Rheum. 1992 May;35(5):516-20. doi: 10.1002/art.1780350505.
OBJECTIVE
To determine the incidence of a clonal lymphoid disease in patients with chronic rheumatoid arthritis (RA) and neutropenia.
METHODS
Lymphocytes from 23 RA patients with either current neutropenia or a history of this complication were studied.
RESULTS
Eight patients had a clonal rearrangement of the T cell receptor beta-chain gene. Phenotypically, they showed a distinctive pattern characterized by an inverted CD4+:CD8+ cell ratio and an increased number and percentage of CD57+/CD8+ and CD3+/DR+ lymphocytes. None had evidence of a lymphoid malignancy.
CONCLUSION
Among RA patients with neutropenia, there is a subset who have a subclinical disease resembling T gamma lymphoproliferative disease.
目的
确定慢性类风湿性关节炎（RA）和中性粒细胞减少患者中克隆性淋巴疾病的发病率。
方法
对23例患有当前中性粒细胞减少或有此并发症病史的RA患者的淋巴细胞进行研究。
结果
8例患者出现T细胞受体β链基因的克隆重排。从表型上看，他们表现出一种独特的模式，其特征是CD4⁺:CD8⁺细胞比例倒置，以及CD57⁺/CD8⁺和CD3⁺/DR⁺淋巴细胞数量和百分比增加。无一例有淋巴恶性肿瘤的证据。
结论
在患有中性粒细胞减少的RA患者中，有一部分患者患有类似于Tγ淋巴细胞增殖性疾病的亚临床疾病。
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