Code R A, Eslin D E, Juliano S L
Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
Exp Brain Res. 1992;88(2):341-4. doi: 10.1007/BF02259109.
The 2-deoxy-glucose (2DG) technique was used to study changes in stimulus-evoked metabolic activity in the somatosensory cortex of the squirrel monkey Saimiri sciureus after unilateral digit amputation. Two to 52 weeks after digit 2 on the left hand was removed, a somatic stimulus was applied to digit 3 bilaterally. In area 3b corresponding to the deafferented side of the brain, the area of stimulus-evoked metabolic activity was greater than that on the opposite, control side of the brain within the same animal. The extent of the topographic projection map of 2DG label in area 3b on the deafferented side of the brain was 1.92 to 4.75 times greater than that on the control side. There was no difference, however, in the topographical area of stimulus-evoked metabolic activity between the left and right somatosensory cortices in a normal, unoperated animal. These data suggest that the changes in functional organization observed using electrophysiological recordings in somatosensory cortex after peripheral denervation may have a metabolic substrate.
采用2-脱氧葡萄糖（2DG）技术，研究松鼠猴（Saimiri sciureus）单侧手指截肢后体感皮层中刺激诱发的代谢活动变化。在切除左手的第二指后2至52周，对双侧第三指施加躯体刺激。在与大脑去传入侧相对应的3b区，同一动物大脑中刺激诱发的代谢活动区域大于对侧对照侧。大脑去传入侧3b区2DG标记的地形投影图范围比对照侧大1.92至4.75倍。然而，在正常未手术动物中，左右体感皮层之间刺激诱发的代谢活动的地形区域没有差异。这些数据表明，在周围神经去传入后，体感皮层中使用电生理记录观察到的功能组织变化可能有代谢底物。
