Barker P A, Murphy R A
Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Canada.
Mol Cell Biochem. 1992 Mar 4;110(1):1-15. doi: 10.1007/BF02385000.
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growth and survival of neurons in the central and peripheral nervous systems. Each of these proteins bind to at least two membrane receptors. One is the low affinity nerve growth factor receptor (p75), which binds each member of the neurotrophin family. The other is one of a family of tyrosine kinase receptors--trkA binds only NGF, the related trkB receptor binds BDNF and NT-3, and trkC binds NT-3 alone. This article reviews kinetic and biochemical information on p75 and its relationship to the trk gene products.
神经生长因子（NGF）、脑源性神经营养因子（BDNF）和神经营养素3（NT-3）是一类结构相关蛋白质的成员，这类蛋白质被称为神经营养因子，可促进中枢和外周神经系统中神经元的生长和存活。这些蛋白质中的每一种都与至少两种膜受体结合。一种是低亲和力神经生长因子受体（p75），它与神经营养因子家族的每个成员结合。另一种是酪氨酸激酶受体家族中的一种——trkA仅结合NGF，相关的trkB受体结合BDNF和NT-3，而trkC仅结合NT-3。本文综述了关于p75的动力学和生化信息及其与trk基因产物的关系。
