Kusumoto M
Department of Radiology, Kobe University School of Medicine.
Nihon Igaku Hoshasen Gakkai Zasshi. 1992 Mar 25;52(3):358-71.
To evaluate utility of Gd-DTPA enhanced MRI (Gd-MRI) in lung cancer, Gd-MRI was performed in 69 cases. 1) Viable tumor was strongly enhanced, necrosis in the tumor, however, was not enhanced on Gd-MRI. Enhanced patterns of Gd-MRI were divided into 3 types, however there was little correlation between the enhancement patterns and histologic types. 2) In serial scan studies of 15 cases, the signal intensity of the tumor reached the peak 3 minutes to 10 minutes after Gd-DTPA administration, and after that the signal intensity decreased gradually. 3) In 23 of 27 (85%) hilar lung cancer cases, Gd-MRI could differentiate the tumor from the peripheral obstructive pneumonia or atelectasis. In 18 of these 23 cases, the peripheral lung disease showed higher intensity than the tumor. 4) In Gd-MRI of pulmonary nodules less than 3 cm in diameter, lung cancers (n = 13) were more strongly enhanced than tuberculomas (n = 5) (p less than 0.001). Based on these data, Gd-MRI was helpful for detecting tumor necrosis and tumor extension on hilar lung cancer with peripheral lung disease. Moreover Gd-MRI may become a feasible diagnostic method for pulmonary nodules.
为评估钆喷酸葡胺增强磁共振成像（Gd - MRI）在肺癌中的应用价值，对69例患者进行了Gd - MRI检查。1）存活肿瘤呈明显强化，然而肿瘤内的坏死区在Gd - MRI上无强化。Gd - MRI的强化模式分为3种类型，但强化模式与组织学类型之间几乎没有相关性。2）在15例患者的连续扫描研究中，肿瘤的信号强度在注射钆喷酸葡胺后3分钟至10分钟达到峰值，之后信号强度逐渐下降。3）在27例肺门肺癌病例中的23例（85%），Gd - MRI能够将肿瘤与周围阻塞性肺炎或肺不张区分开来。在这23例中的18例，周围肺部疾病的信号强度高于肿瘤。4）在直径小于3 cm的肺结节的Gd - MRI检查中，肺癌（n = 13）的强化程度高于结核瘤（n = 5）（p < 0.001）。基于这些数据，Gd - MRI有助于检测伴有周围肺部疾病的肺门肺癌的肿瘤坏死和肿瘤范围。此外，Gd - MRI可能成为一种可行的肺结节诊断方法。
