Ayraud N, Reboul R
C R Seances Soc Biol Fil. 1975;169(5):1326-32.
Isoniazid gives rise to chromomerization of human bone marrow metaphase chromosomes in vitro or in vivo. The discontinuous appearance of the chromatids seems to be related to their progressive spiralization during the mitotic division. The medicinal substance tested would have the property of revealing the distribution of heterogenous chromatine by showing down its condensation procedure.
异烟肼在体内外均可引起人骨髓中期染色体的染色粒形成。染色单体的间断出现似乎与其在有丝分裂过程中的渐进螺旋化有关。所测试的药物物质可能具有通过减缓其凝聚过程来揭示异染色质分布的特性。
