Patrone F, Dallegri F, Ottonello L, Ballestrero A, Bogliolo F, Ferrando F, Sacchetti C
Dipartimento di Medicina Interna dell' Universita' degli Studi di Genova, Italy.
Thymus. 1992;19 Suppl 1:S89-96.
We report the results of our in vitro experiments on the effects of an L-Arg terminal synthetic hypoxanthine derivative (ST 789) on human neutrophil function. To verify the hypothesis that the reported immunomodulatory effects of ST 789 in vivo are accounted for, at least in part, by effects on phagocytic cells, we experimented in parallel also with methisoprinol, a well known stimulator of neutrophil chemotaxis, structurally related to ST 789. Our results demonstrate that ST 789 is able to improve the true chemotactic response of human neutrophils without interfering with other phagocytic functions, following a pattern largely shared by methisoprinol. Accordingly, ST 789 may be able, when used in vivo, to prime neutrophils for timely and efficient migration to inflammatory sites, and it could be considered for therapeutic use in patients with impaired inflammatory response or severe infections.
我们报告了体外实验的结果，该实验研究了L-精氨酸末端合成次黄嘌呤衍生物（ST 789）对人中性粒细胞功能的影响。为了验证ST 789在体内所报道的免疫调节作用至少部分是由对吞噬细胞的作用所导致这一假设，我们还同时使用了与ST 789结构相关的、众所周知的中性粒细胞趋化性刺激剂美替沙腙进行实验。我们的结果表明，ST 789能够改善人中性粒细胞的真正趋化反应，而不干扰其他吞噬功能，这一模式与美替沙腙在很大程度上是相同的。因此，ST 789在体内使用时可能能够使中性粒细胞做好准备，以便及时、有效地迁移到炎症部位，并且对于炎症反应受损或严重感染的患者，它可以被考虑用于治疗。
