[Effect of leukemic sera on the reactivity of leukocytes from acute leukemia patients in mixed lymphocyte cultures].

The author examined the action of leucemic sera (first attack, repapse and remission) on the reactivity of lymphocytes, obtained from patients with acute myeloblastic (AML) in mixed cultures of lymphocytes, which was compared with the reactivity in the medium of fetal calf serum and pool of normal human serum. Twelve out of 21 Leucemic sera, obtained from patients with AML during their first attack or relapse inhibited completely the mixed lympholytec cultures under autologic conditions. Eight leucemic sera with established inhibiting action under autologic conditions preserved it under allogenic conditions as well. Sera of patients with acute myeloblastic leucosis during remission did not have inhibiting action on mixed lymphocytic cultures. These results suggested the presence of factor(s) in the sera of patients with acute myeloblastic leucosis during the first attack or relapse, which inhibited mixed lymphocytic cultures.