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[在比利时,作为参考细菌的大肠杆菌对阿莫西林/克拉维酸联合制剂的耐药性是否有所增加?]

[Is there in Belgium an increase in resistance to the combination amoxicillin/clavulanic acid of Escherichia coli as reference bacteria?].

作者信息

Yourassowsky E, Van der Linden M P, MacGilavry G B, Glupczynsky Y

机构信息

Département de Microbiologie, Hôpital Universitaire Brugmann, Bruxelles.

出版信息

Acta Clin Belg. 1992;47(1):15-20. doi: 10.1080/17843286.1992.11718205.

DOI:10.1080/17843286.1992.11718205
PMID:1317079
Abstract

The difficulties encountered in measuring the susceptibility of the association amoxicillin/clavulanate can be a cause for disagreements between laboratories. With an inoculum standardized at 10(4) CFU/spot, the resistance level of E. coli approaches 10%. If the variety of current methods is taken into account, the evaluation of a resistance increase can only be an internal one, specific for each laboratory, provided that methods do not change in the course of time.

摘要

测量阿莫西林/克拉维酸联合制剂敏感性时遇到的困难可能导致实验室之间出现分歧。接种物标准化为每点10⁴CFU时,大肠杆菌的耐药水平接近10%。如果考虑到当前方法的多样性,只有在方法随时间不变的情况下,对耐药性增加的评估才只能是每个实验室特有的内部评估。

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引用本文的文献

1
Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli.大肠杆菌对阿莫西林与克拉维酸联合用药的耐药发生率及机制
Antimicrob Agents Chemother. 1995 Nov;39(11):2478-83. doi: 10.1128/AAC.39.11.2478.