通过对儿童慢性肉芽肿病的研究来描绘吞噬细胞NADPH氧化酶。

Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.

作者信息

Gallin J I, Leto T L, Rotrosen D, Kwong C H, Malech H L

机构信息

National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

出版信息

Curr Opin Immunol. 1992 Feb;4(1):53-6. doi: 10.1016/0952-7915(92)90124-w.

DOI:10.1016/0952-7915(92)90124-w

PMID:1317712

Abstract

The phagocyte NADPH oxidase is a complex system consisting of membrane and cytosolic components that must assemble at the membrane for proper activation. Studies of patients with chronic granulomatous diseases of childhood have enabled the molecular characterization of these components, which has led to studies defining their interaction during NADPH complex assembly. Understanding NADPH oxidase assembly provides an opportunity to develop therapeutics for the regulation of this important reaction of inflammation.

摘要

吞噬细胞NADPH氧化酶是一个复杂的系统，由膜成分和胞质成分组成，这些成分必须在膜上组装才能正常激活。对儿童慢性肉芽肿病患者的研究使这些成分得以进行分子特征分析，进而开展了有关确定它们在NADPH复合物组装过程中相互作用的研究。了解NADPH氧化酶的组装为开发调控这一重要炎症反应的治疗方法提供了契机。