呼吸爆发氧化酶。

The respiratory burst oxidase.

作者信息

Babior B M

机构信息

Division of Biochemistry, Research Institute of Scripps Clinic, La Jolla, California.

出版信息

Hematol Oncol Clin North Am. 1988 Jun;2(2):201-12.

PMID:2839456

Abstract

The respiratory burst oxidase is an activatable, membrane-bound flavo(?hemo) protein that catalyzes the NADPH-dependent reduction of oxygen to superoxide (O2-) in stimulated phagocytes. Chronic granulomatous disease, a group of disorders in which phagocytes cannot manufacture O2-, is caused by a biochemical lesion involving this oxidase or its activating system.

摘要

呼吸爆发氧化酶是一种可激活的膜结合黄素（？血红素）蛋白，在受刺激的吞噬细胞中催化NADPH依赖的氧还原为超氧化物（O2-）。慢性肉芽肿病是一组吞噬细胞无法产生O2-的疾病，由涉及该氧化酶或其激活系统的生化损伤引起。