Sixsmith D
J Pharm Pharmacol. 1977 Jan;29(1):33-6. doi: 10.1111/j.2042-7158.1977.tb11233.x.
Tablets have been prepared from previously characterized microcrystalline cellulose (Avicel) powders, using an instrumented single station tablet machine. The regenerated particle size was found to increase in compaction pressure. Compaction caused a slight initial decrease in B.E.T. surface area, followed by an increase mainly as a result of elastic recovery of the particles. The intra-particulate pore size distribution showed no change throughout the range of compaction pressures studied, demonstrating that the internal pores did not collapse. Measurement of the interparticulate porosity by mercury porosimetry, liquid penetration techniques and scanning electron microscopy showed a decrease in this parameter with increase in compaction pressure. The dissolution behaviour from the compacts showed in general a decreased rate with increase in compaction pressure, that from the cellulose grade PH 105 being slower than from the remaining grades.
使用配备仪器的单站压片机，由先前表征过的微晶纤维素（微晶纤维素）粉末制备片剂。发现再生粒径随压制压力增加而增大。压制导致B.E.T.表面积最初略有下降，随后主要由于颗粒的弹性恢复而增加。在所研究的压制压力范围内，颗粒内孔径分布没有变化，表明内部孔隙没有塌陷。通过压汞法、液体渗透技术和扫描电子显微镜测量颗粒间孔隙率，结果表明该参数随压制压力增加而降低。压片的溶出行为总体上显示，随着压制压力增加，溶出速率降低，纤维素等级PH 105的溶出速率比其他等级慢。
