胶体二氧化硅作为乳糖、对乙酰氨基酚、土霉素及其混合物助流剂的作用。
The action of colloidal silicon dioxide as a glidant for lactose, paracetamol, oxytetracycline and their mixtures.
作者信息
Varthalis S, Pilpel N
出版信息
J Pharm Pharmacol. 1977 Jan;29(1):37-40. doi: 10.1111/j.2042-7158.1977.tb11234.x.
Abstract
Anomalies are observed in some of the physical and mechanical properties of mixtures of lactose, paracetamol and oxytetracycline when small amounts of colloidal silicon dioxide are added to them. Owing to its differing propensities to coat the particles of the host powders, the silicon dioxide acts as a glidant for the lactose and paracetamol, but as an antiglidant for the oxytetracycline.
摘要
当向乳糖、对乙酰氨基酚和土霉素的混合物中加入少量胶体二氧化硅时，会观察到其一些物理和机械性能出现异常。由于二氧化硅包覆主体粉末颗粒的倾向不同，它对乳糖和对乙酰氨基酚起助流剂作用，但对土霉素起抗流剂作用。
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