Odeleye O E, Lopez M C, Smith B T, Eskelson C D, Watson R R
Department of Family Medicine, University of Arizona, Tucson 85724.
Can J Physiol Pharmacol. 1992 Mar;70(3):338-43. doi: 10.1139/y92-042.
Effects of cocaine administration on lipid peroxidation and liver damage in immunocompromised mice fed different levels of dietary proteins were investigated. Indices of lipid peroxidation and serum aminotransferases as evidence of free radical attack and liver damage were compared in mice fed a low protein (4%) or regular protein diet (20% protein) for 3 weeks and then infected with murine leukemia virus and given daily intraperitoneal injections of increasing progressive doses of 5-45 mg.kg-1.day-1 of cocaine for 11 weeks. Cocaine administration significantly increased hepatic triglycerides, serum aminotransaminases, conjugated dienes, lipid fluorescence, and malondialdehyde levels. These changes were exacerbated by retroviral infection and also by protein undernutrition. Retroviral infection additively increased indices of cocaine-induced lipid peroxidation and hepatic damage. Significant increases in indices of lipid peroxidation and greater liver injury were also detected in similarly treated mice that received the low protein diet compared with well-nourished mice. These results show that immunocompromised mice fed low levels of dietary protein form significantly increased immunogenic lipid peroxidation adducts during cocaine treatment.
研究了给予可卡因对不同膳食蛋白质水平的免疫受损小鼠脂质过氧化和肝损伤的影响。比较了喂食低蛋白（4%）或常规蛋白饮食（20%蛋白质）3周，然后感染鼠白血病病毒并每天腹腔注射递增剂量（5 - 45毫克·千克⁻¹·天⁻¹）可卡因11周的小鼠的脂质过氧化指标和血清氨基转移酶，以此作为自由基攻击和肝损伤的证据。给予可卡因显著增加了肝脏甘油三酯、血清氨基转移酶、共轭二烯、脂质荧光和丙二醛水平。这些变化因逆转录病毒感染以及蛋白质营养不良而加剧。逆转录病毒感染叠加增加了可卡因诱导的脂质过氧化和肝损伤指标。与营养良好的小鼠相比，接受低蛋白饮食的类似处理小鼠的脂质过氧化指标也显著增加，且肝损伤更严重。这些结果表明，在可卡因治疗期间，喂食低水平膳食蛋白质的免疫受损小鼠会形成显著增加的免疫原性脂质过氧化加合物。
