人B细胞在严重联合免疫缺陷小鼠中诱导淋巴瘤
Lymphoma induction by human B cells in scid mice.
作者信息
Amadori A, Veronese M L, Mazza M R, Zamarchi R, Mion M, D'Andrea E, Menin C, Del Mistro A, Leszl A, Calderazzo F
机构信息
Institute of Oncology, University of Padova, Italy.
出版信息
Leukemia. 1992;6 Suppl 3:23S-25S.
Lymphoma development was studied in scid mice injected i.p. with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations prevented lymphoma development in all mice, suggesting that T-cell-derived factors are involved in the expansion of the latently EBV-infected B-cell population within the immunodeficient host.
通过向严重联合免疫缺陷（scid）小鼠腹腔注射来自EBV阳性供体的外周血单核细胞（PBMC）来研究淋巴瘤的发展。大多数注射后的小鼠在接种后4个月内出现寡克隆/单克隆B细胞肿瘤；在肿瘤细胞中发现了EBV基因组。从注射的细胞群体中去除T淋巴细胞可防止所有小鼠发生淋巴瘤，这表明T细胞衍生因子参与了免疫缺陷宿主中潜伏性EBV感染的B细胞群体的扩增。
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