Gardiner G W, Lajoie G, Keith R
Department of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada.
Histopathology. 1992 Jun;20(6):541-4. doi: 10.1111/j.1365-2559.1992.tb01044.x.
An adenocarcinoma of the papilla of Vater showing hepatoid differentiation similar to that described for hepatoid adenocarcinoma of the stomach is reported. The tumor was a poorly differentiated adenocarcinoma with clear cells containing occasional hyaline droplets and exhibiting bile secretion. Alpha-fetoprotein (AFP), alpha 1-antitrypsin (alpha 1-AT) and carcino-embryonic antigen (CEA) were demonstrated by immunoperoxidase staining. This appears to be the first report of a hepatoid adenocarcinoma at this location.
