Golovinsky E V, Maneva L S, Angelov I I, Veljanova K D, Sniker D J, Stankevich E K
Neoplasma. 1976;23(1):43-6.
The effect of several derivatives of ureidosuccinic acid on the growth of Escherichia coli 387, Staphylococcus aureus strain 209 and its mutant UV-2, Sarcina lutea, Candida tropicalis and Neurospora crossa 9863 as pre-screening systems for antitumor activity was studied. It was found that dihydrazide of D,L-ureidosuccinic acid (DHUA) had a marked antibacterial activity. The inhibitory effect of DHUA on N. crassa could not be removed by aspartic acid, ureidosuccinic acid, dihydroorotic acid, orotic acid, uracil or cytosine. DHUA suppressed the growth of Myeloma P-8 by 38%, that of Sarcoma 180 by 12% and that of Yoshida sarcoma by 19%. No effect was found on the growth of Lymphosarcoma Pliss.
研究了几种脲基琥珀酸衍生物对大肠杆菌387、金黄色葡萄球菌209株及其突变体UV - 2、藤黄八叠球菌、热带假丝酵母和粗糙脉孢菌9863生长的影响，以此作为抗肿瘤活性的预筛选系统。发现D,L-脲基琥珀酸二酰肼（DHUA）具有显著的抗菌活性。天冬氨酸、脲基琥珀酸、二氢乳清酸、乳清酸、尿嘧啶或胞嘧啶均不能消除DHUA对粗糙脉孢菌的抑制作用。DHUA使骨髓瘤P - 8的生长抑制38%，肉瘤180的生长抑制12%，吉田肉瘤的生长抑制19%。对普利斯氏淋巴肉瘤的生长未发现影响。
