Lacord-Bonneau M, Picard J, Dubernard L
Nutr Metab. 1975;18(5-6):225-39.
Glycosaminoglycans (GAG) from brains, intestines, livers and skin of rats were analyzed by electrophoretic and enzymatic methods. Variations in GAG distribution have been studied in rats fed on a vitamin-A-deficient diet and on a diet supplemented with an excessive quantity of vitamin A. Hypervitaminosis A resulted in a decrease in GAG isolated from connective and hepatic tissues. The incorporation of labeled sulfate into the GAG of these tissues has been studied. Hypervitaminosis A resulted in a decrease in sulfate incorporation into the GAG isolated from connective tissues. A large increase in sulfate incorporation into the GAC of the digestive tract is observed for vitamin-A-treated rats. A decrease is noted for vitamin-A-deficient rats. It was suggested that these variations in distribution and specific activity of GAG could be due to different effects of vitamin A. Vitamin A seems to be required either for the release of lysosomal enzymes or for the sulfatation and elongation of certain glucidic chains in the biosynthesis of sulfated GAG.
采用电泳和酶法分析了大鼠脑、肠、肝和皮肤中的糖胺聚糖（GAG）。研究了喂食维生素A缺乏饮食和补充过量维生素A饮食的大鼠中GAG分布的变化。维生素A过多症导致从结缔组织和肝组织中分离出的GAG减少。研究了标记硫酸盐掺入这些组织的GAG中的情况。维生素A过多症导致从结缔组织中分离出的GAG中硫酸盐掺入减少。对于经维生素A处理的大鼠，观察到其消化道GAC中硫酸盐掺入大幅增加。维生素A缺乏的大鼠则减少。有人认为，GAG分布和比活性的这些变化可能是由于维生素A的不同作用。维生素A似乎是溶酶体酶释放所必需的，或者是硫酸化GAG生物合成中某些糖链硫酸化和延长所必需的。
