LEDINKO N, MELNICK J L
J Exp Med. 1954 Sep 1;100(3):247-67. doi: 10.1084/jem.100.3.247.
The inhibition of multiplication of one poliomyelitis virus by a poliomyelitis virus of another immunologic type has been established by using tissue cultures of monkey testes. The degree of interference varied from none, to partial, to complete, depending upon the time between inoculation of the interfering and the challenge viruses, and the amount of each virus inoculated. Reciprocal interference was demonstrated between Types 1, 2, and 3 poliomyelitis viruses. Under conditions which resulted in complete suppression of the growth of one poliomyelitis virus by another, interference by poliomyelitis virus with the multiplication of four antigenically distinct "orphan" viruses and of three antigenically related strains of Coxsackie virus could not be demonstrated. Poliomyelitis virus rendered non-infective by formalin or by irradiation with high energy electrons or with ultraviolet light, or treated so that only traces of residual active virus remained, failed to interfere with the propagation of active homologous virus.
利用猴睾丸组织培养已证实,一种免疫类型的脊髓灰质炎病毒可抑制另一种免疫类型脊髓灰质炎病毒的增殖。干扰程度从无、部分到完全不等,这取决于接种干扰病毒和攻击病毒之间的时间间隔以及每种病毒的接种量。1型、2型和3型脊髓灰质炎病毒之间存在相互干扰。在一种脊髓灰质炎病毒完全抑制另一种脊髓灰质炎病毒生长的条件下,未证实脊髓灰质炎病毒对四种抗原性不同的“孤儿”病毒以及三种抗原相关的柯萨奇病毒株的增殖有干扰作用。经福尔马林处理、高能电子照射或紫外线照射而失去感染性,或经处理仅残留微量活性病毒的脊髓灰质炎病毒,不能干扰活性同源病毒的繁殖。