淋巴结细胞转移的研究。IV. 受体兔经X射线照射对细胞转移后抗体出现的影响。
Studies on the transfer of lymph node cells. IV. Effects of X-irradiation of recipient rabbits on the appearance of antibody after cell transfer.
作者信息
HARRIS T N, HARRIS S, BEALE H D, SMITH J J
出版信息
J Exp Med. 1954 Sep 1;100(3):289-300. doi: 10.1084/jem.100.3.289.
Cells of the popliteal lymph node were teased 3 days after the injection of Shigella paradysenteriae into the hind foot pads of rabbits. These cells were transferred to normal and x-irradiated recipients. It was noted that the serum titers of dysentery agglutinins in irradiated recipients were higher than in normal recipients. This was represented both in a higher peak: titer and a tendency to remain higher for a longer period than in normal animals. Recipients were x-irradiated within 1 hour after receiving cells of the lymph node prepared as indicated above. The serum titers of these recipients were markedly reduced in comparison with those of non-irradiated control animals. If the irradiation of the recipients followed the transfer of cells by a day, however, this difference was much smaller and in the case of a 2 day interval after the transfer of the lymph node cells the irradiation appeared to have no effect on the resulting serum titer.
在将副痢疾志贺菌注射到兔后足垫3天后，取出腘淋巴结的细胞。将这些细胞转移至正常和经X射线照射的受体动物。结果发现，经照射的受体动物体内痢疾凝集素的血清效价比正常受体动物更高。这表现为更高的峰值效价，并且与正常动物相比，在较长时间内保持较高水平的趋势。受体动物在按上述方法制备的淋巴结细胞转移后1小时内接受X射线照射。与未照射的对照动物相比，这些受体动物的血清效价显著降低。然而，如果受体动物在细胞转移一天后接受照射，这种差异要小得多，并且在淋巴结细胞转移后间隔两天进行照射的情况下，照射似乎对最终的血清效价没有影响。
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