[3H-叔丁基双环邻苯二甲酸酯——一种新型γ-氨基丁酸A受体氯离子通道配体]
[3H-tert-butylbicyclo-ortho-benzoate--a new ligand for chloride ion channel of GABA-A receptor].
作者信息
Golovko A I, Sofronov G A
出版信息
Biull Eksp Biol Med. 1992 Feb;113(2):155-6.
PMID:1319233
Abstract
The study was made of the binding of 35S-t-butylbicyclophosphorothionate and 3H-t-butylbicycloorthobenzoate (TBOB) which label a GABAA receptor-regulated chloride ionophores to glass fiber filters GF/B and GF/C. The rate of 3H-TBOB binding was higher. GABA displayed a biphasic effect on 3H-TBOB binding to rat brain synaptic membrane; enhancement at low concentrations of the agent and inhibition at higher ones. The results suggest that GABA may modulate the 3H-TBOB binding.
摘要
该研究针对标记GABAA受体调节氯离子通道的35S-叔丁基双环硫代磷酸酯和3H-叔丁基双环原苯甲酸酯（TBOB）与玻璃纤维滤器GF/B和GF/C的结合情况展开。3H-TBOB的结合速率更高。γ-氨基丁酸（GABA）对3H-TBOB与大鼠脑突触膜的结合呈现双相效应；低浓度时增强，高浓度时抑制。结果表明，GABA可能调节3H-TBOB的结合。
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