Colbert C M, Burger B S, Levy W B
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Brain Res. 1992 Jan 31;571(1):159-61. doi: 10.1016/0006-8993(92)90524-d.
This study used urethane-anesthetized rats to investigate the longevity of heterosynaptically evoked depression of the monosynaptic response generated by synapses between entorhinal cortical (EC) afferents and the cells of the dentate gyrus (DG). Brief, high-frequency activation of the converging ipsilateral EC-DG input depressed the synaptic response of the contralateral EC-DG synapses without prior experimentally induced potentiation. This depression lasted for hours. Such observations are consistent with a role for heterosynaptically induced long-term depression in the encoding functions of synapses.
本研究使用经氨基甲酸乙酯麻醉的大鼠，以研究内嗅皮质（EC）传入纤维与齿状回（DG）细胞之间突触所产生的单突触反应的异突触诱发抑制的持续时间。短暂、高频激活同侧汇聚的EC-DG输入，在没有事先实验诱导增强的情况下，抑制了对侧EC-DG突触的突触反应。这种抑制持续了数小时。这些观察结果与异突触诱导的长期抑制在突触编码功能中的作用一致。
