甲基黄嘌呤与髓过氧化物酶的相互作用。一种抗炎机制。
Interaction of methyl-xanthines with myeloperoxidase. An anti-inflammatory mechanism.
作者信息
van Zyl J M, Kriegler A, van der Walt B J
机构信息
Department of Pharmacology, Faculty of Medicine, University of Stellenbosch, Tygerberg, South Africa.
出版信息
Int J Biochem. 1992 Jun;24(6):929-35. doi: 10.1016/0020-711x(92)90099-m.
PMID:1319356
Abstract
- Inhibition of myeloperoxidase (MPO)-catalyzed reactions by methyl-substituted xanthines has been investigated. 2. Except for theobromine and caffeine, all xanthines tested were potent inhibitors of the MPO-H2O2-Cl- system. 3. In contrast to methyl substitution in the 1 or 8 position of xanthine, substitution in the 3 or 7 position had a marked effect on the inhibition of MPO catalysis. 4. Two different inhibitory mechanisms were induced; scavenging of hypochlorous acid (HOCl) generated by the MPO system and accumulation of Compound II (ferryl MPO) which is inactive as a catalyst of Cl- oxidation.
摘要
- 已对甲基取代的黄嘌呤对髓过氧化物酶（MPO）催化反应的抑制作用进行了研究。2. 除了可可碱和咖啡因外，所有测试的黄嘌呤都是MPO-H2O2-Cl-系统的强效抑制剂。3. 与黄嘌呤1位或8位的甲基取代不同，3位或7位的取代对MPO催化的抑制有显著影响。4. 诱导了两种不同的抑制机制；清除MPO系统产生的次氯酸（HOCl）和积累作为Cl-氧化催化剂无活性的化合物II（高铁MPO）。
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