Dayer J M
Division of Immunology and Allergy, University Hospital, Geneva, Switzerland.
J Rheumatol Suppl. 1992 Jan;32:59-60.
Cytokines play a crucial role in the inflammatory and immune responses. The activity of cytokines is counterbalanced by specific inhibitors with some functioning as receptor antagonists. Inhibitors to interleukin 1 and tumor necrosis factor may have therapeutic potential in conditions such as inflammatory arthritis, diabetes mellitus, disseminated intravascular coagulopathy and septic shock. The ability to modulate host defenses with cytokines and cytokine antagonists may also have applications in the fields of transplantation, oncohematology and immunodeficiency.
细胞因子在炎症和免疫反应中发挥着关键作用。细胞因子的活性由特定抑制剂进行平衡，其中一些抑制剂起受体拮抗剂的作用。白细胞介素1和肿瘤坏死因子的抑制剂在炎性关节炎、糖尿病、弥散性血管内凝血和感染性休克等病症中可能具有治疗潜力。利用细胞因子和细胞因子拮抗剂调节宿主防御的能力在移植、肿瘤血液学和免疫缺陷领域也可能有应用。
