Miossec P
Laboratoire d'immunologie, INSERM U80, hôpital E Herriot, Lyon, France.
Pediatrie. 1991;46(2):135-9.
Interleukin 1 (IL 1), tumor necrosis factor or alpha and Interleukin 6 are members of a family of soluble factors or cytokines which have multiple biologic activities and play a major role in host defence and in the pathogenesis of various diseases. They act at a low concentration on specific receptors. Their role includes host defence with fever, inflammatory cell migration, activation of immune cells, destruction of bone and cartilage. IL 1 activities are included in a cytokine network which amplifies and regulates the effects of numerous cytokines. Current research is aimed at obtaining drugs capable of modulating the effects of these cytokines.
白细胞介素1（IL - 1）、肿瘤坏死因子α和白细胞介素6是可溶性因子或细胞因子家族的成员，它们具有多种生物学活性，在宿主防御和各种疾病的发病机制中起主要作用。它们以低浓度作用于特定受体。其作用包括引起发热以进行宿主防御、炎症细胞迁移、免疫细胞激活以及骨和软骨破坏。IL - 1的活性包含在一个细胞因子网络中，该网络放大并调节多种细胞因子的作用。目前的研究旨在获得能够调节这些细胞因子作用的药物。
