Kudriavtseva N N, Bakshtanovskaia I V, Madorskaia I A, Popova N K, Marona-Lewicka D, Vetulani I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1992;92(1):106-9.
A study was made of the influence of the antidepressants imipramine and citalopram (10 mg/kg, chronic administration, i.p.) on the depression-like condition in submissive male rats. The above condition developed under the effect of chronic emotional stress because of successive experience of defeat in social confrontations (Kudryavtseva, Bakshtanovskaya, 1988). Imipramine rather than citalopram exerted a remarkable antidepressive effect recorded by the Porsolt's test. Measurements of the content of serotonin, dopamine and noradrenaline in brain structures have demonstrated changes in the serotoninergic and catecholaminergic systems in males with the depressive symptomatology in relation to intact animals. It should be mentioned that at different stages of pathological process formation, the role of certain structures and mediator systems underwent definite changes.
研究了抗抑郁药丙咪嗪和西酞普兰（10毫克/千克，腹腔注射，长期给药）对顺从雄性大鼠抑郁样状态的影响。上述状态是在慢性情绪应激的作用下，由于在社会对抗中连续经历失败而产生的（库德里亚夫采娃、巴克什塔诺夫斯卡娅，1988年）。通过波索尔特试验记录发现，丙咪嗪而非西酞普兰具有显著的抗抑郁作用。对脑结构中血清素、多巴胺和去甲肾上腺素含量的测量表明，与正常动物相比，出现抑郁症状的雄性大鼠的血清素能和儿茶酚胺能系统发生了变化。应当指出的是，在病理过程形成的不同阶段，某些结构和介质系统的作用发生了一定的变化。
