Balaban E P, Walker B S, Cox J V, Bordlee R P, Salk D, Abrams P G, Sheehan R G, Frenkel E P
Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas 75235-8852.
Clin Nucl Med. 1992 Jun;17(6):439-45. doi: 10.1097/00003072-199206000-00002.
Tumor-associated radiolabeled monoclonal antibodies (MoAb) can detect neoplasms in a variety of settings. The authors conducted a study comparing the ability to detect and stage small cell lung carcinoma by using a Tc-99m labeled monoclonal antibody (NR-LU-10 Fab) (NeoRx Corp, Seattle, WA) with standard staging methods. Standard staging included a physical examination, chest x-ray, a battery of radionuclide scans and/or computerized tomographic studies (head, abdomen, and bone), and bone marrow examination. A total of 22 comparisons were performed in 17 patients (five patients had reevaluations after therapy). Fifty-four (74%) of the 73 lesions defined by standard staging were detected by the radiolabeled MoAb. Seven of eight patients (88%) classified by standard staging as having "limited stage" disease on presentation were concordantly "limited stage" by radioimmunoimaging. One patient deemed "limited stage" by standard staging was correctly upstaged (bone marrow involvement) as a result of the radiolabeled MoAb. Two patients found to have extensive disease at diagnosis were characterized as "limited stage" by the MoAb, for an overall staging accuracy of 0.88. Thirteen of 19 missed lesions were smaller than 2 cm (10 were smaller than 1 cm; 3 measured 1 to 2 cm). This comparative study shows that radioimmunoimaging by Tc-99m labeled NR-LU-10 Fab antibody is capable of complementing standard staging methods used in the evaluation of small cell lung carcinoma.
肿瘤相关放射性标记单克隆抗体（MoAb）可在多种情况下检测肿瘤。作者进行了一项研究，比较使用锝-99m标记的单克隆抗体（NR-LU-10 Fab）（NeoRx公司，华盛顿州西雅图）与标准分期方法检测和分期小细胞肺癌的能力。标准分期包括体格检查、胸部X线、一系列放射性核素扫描和/或计算机断层扫描研究（头部、腹部和骨骼）以及骨髓检查。对17例患者共进行了22次比较（5例患者在治疗后进行了重新评估）。标准分期确定的73个病变中，有54个（74%）被放射性标记的MoAb检测到。8例初诊时经标准分期分类为“局限期”疾病的患者中，有7例（88%）经放射免疫显像也为“局限期”。1例经标准分期判定为“局限期”的患者因放射性标记的MoAb被正确上调分期（骨髓受累）。2例诊断时发现有广泛病变的患者经MoAb判定为“局限期”，总体分期准确率为0.88。19个漏诊病变中有13个小于2 cm（10个小于1 cm；3个为1至2 cm）。这项比较研究表明，锝-99m标记的NR-LU-10 Fab抗体放射免疫显像能够补充用于评估小细胞肺癌的标准分期方法。
