病毒病因（MMTV）的转移性小鼠乳腺肿瘤中NM23基因表达降低。
Decreasing expression of NM23 gene in metastatic murine mammary tumors of viral etiology (MMTV).
作者信息
Caligo M A, Cipollini G, Cope Di Valromita A, Bistocchi M, Bevilacqua G
机构信息
Institute of Pathological Anatomy and Histology, University of Pisa, Italy.
出版信息
Anticancer Res. 1992 May-Jun;12(3):969-73.
Murine mammary tumors induced by the Murine Mammary Tumor Virus (MMTV) were chosen to study the expression of the NM23 gene during the metastatic process because of their viral etiology, different from that of the previously reported experimental tumor systems. NM23 mRNA levels are higher in non metastatic tumors than in metastatic ones. Moreover, the NM23 expression is higher in tumors induced by the C3H variant of the MMTV than in tumors induced by the RIII variant. These data are a further support to the hypothesis of a basic role of the NM23 gene in the down-regulation of tumor progression.
由于鼠乳腺肿瘤病毒（MMTV）诱发的小鼠乳腺肿瘤具有病毒病因，与先前报道的实验性肿瘤系统不同，因此被选来研究NM23基因在转移过程中的表达。非转移性肿瘤中的NM23 mRNA水平高于转移性肿瘤。此外，MMTV的C3H变种诱发的肿瘤中NM23的表达高于RIII变种诱发的肿瘤。这些数据进一步支持了NM23基因在下调肿瘤进展中起基本作用这一假说。
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