o,p'-滴滴滴治疗导致的可逆性精神衰退和神经功能障碍。

Reversible mental deterioration and neurological disturbances with o,p'-DDD therapy.

作者信息

Bollen E, Lanser J B

机构信息

Department of Neurology, University Hospital, Leiden, The Netherlands.

出版信息

Clin Neurol Neurosurg. 1992;94 Suppl:S49-51. doi: 10.1016/0303-8467(92)90020-4.

DOI:10.1016/0303-8467(92)90020-4

PMID:1320517

Abstract

A patient with serious neurological and neuropsychological side-effects of a 2-year treatment with 1,1-dichloro-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p'-DDD) for adrenal carcinoma showed complete recovery after discontinuation of the drug. Studying a larger number of patients during and after long term treatment with o,p'-DDD is indicated. If results of this report are confirmed, therapy should not be discontinued even if serious side effects occur.

摘要

一名因肾上腺癌接受1,1-二氯-（邻氯苯基）-2-（对氯苯基）乙烷（邻，对'-滴滴滴）治疗两年后出现严重神经和神经心理副作用的患者，在停药后完全康复。建议对更多接受邻，对'-滴滴滴长期治疗期间及之后的患者进行研究。如果本报告结果得到证实，即使出现严重副作用，治疗也不应中断。