Futterweit W, Green G, Tarlin N, Dunaif A
Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York.
Fertil Steril. 1992 Jul;58(1):124-8.
To evaluate the role of chronic long-term exogenous androgen administration to normal ovulatory women on adrenal steroidogenesis.
Prospective study of four consecutive female-to-male transsexuals before and during chronic testosterone (T) therapy.
Clinical Research Center of the Mount Sinai Medical Center.
Four female-to-male transsexuals were studied before and during 6 to 12 months of chronic T enanthate therapy for desired virilization. All four subjects were ovulatory before treatment. Adrenocorticotropic hormone (ACTH) testing was performed before, and 6 and 12 months of androgen therapy and various adrenal androgens as well as precursor:product pairs were evaluated as an index of specific adrenocortical biosynthetic defects.
Baseline and 1 hour after 0.25 mg ACTH intravenously, adrenal androgen levels as well as adrenal precursor/product pairs demonstrated no difference before and during chronic T treatment. Studies included determinations of plasma 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone, androstenedione, 11-deoxycortisol, and cortisol.
It is concluded that chronic hypertestosteronemia does not alter adrenal steroidogenesis.
评估长期给予正常排卵女性外源性雄激素对肾上腺类固醇生成的作用。
对四名连续的女性变男性易性癖者在慢性睾酮（T）治疗前及治疗期间进行前瞻性研究。
西奈山医学中心临床研究中心。
对四名女性变男性易性癖者在接受6至12个月的长效庚酸睾酮治疗以实现预期的男性化之前及期间进行研究。所有四名受试者在治疗前均有排卵。在雄激素治疗前、治疗6个月和12个月时进行促肾上腺皮质激素（ACTH）测试，并评估各种肾上腺雄激素以及前体：产物对，作为特定肾上腺皮质生物合成缺陷的指标。
静脉注射0.25 mg ACTH后基线及1小时时，慢性T治疗前和治疗期间肾上腺雄激素水平以及肾上腺前体/产物对均无差异。研究包括测定血浆17-羟孕烯醇酮、17-羟孕酮、脱氢表雄酮、雄烯二酮、11-脱氧皮质醇和皮质醇。
得出的结论是，慢性高雄激素血症不会改变肾上腺类固醇生成。
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