Increased responses to adenosine and 2-chloroadenosine of cyclic AMP-generating systems in the primary cortical region of cobalt-induced epilepsy in the rat.

The epileptic activity was induced by an injection of cobalt chloride solution into the unilateral sensorimotor cortex of rats. Cyclic AMP accumulations elicited by adenosine and 2-chloroadenosine were investigated in slices from different regions of the epileptic cortex. The cyclic AMP accumulation was increased in the primary cortical region of cobalt-induced epilepsy. The greatest increase in cyclic AMP accumulation was detected between 2 and 3 weeks after treatment by cobalt, in conjunction with the electrographic and behavioral findings. The results suggest the functional significance of cortical cyclic AMP-generating systems in cobalt-induced epilepsy.