Rosenthal M A, Webster P J, Gebski V J, Stuart-Harris R C, Langlands A O, Boyages J
Westmead Hospital, NSW.
Med J Aust. 1992 May 4;156(9):605-10. doi: 10.5694/j.1326-5377.1992.tb121456.x.
To determine the cost of treating small cell lung cancer (SCLC) and to assess quality-adjusted survival in these patients.
Retrospective analysis.
Westmead Hospital, a tertiary referral institution.
Consecutive sample of 31 patients with histologically proved SCLC, treated between January 1987 and December 1987.
The cost of investigation, hospitalisation, chemotherapy, radiotherapy and follow-up of patients overall and for those with limited and extensive disease respectively. Quality-adjusted survival was based on a Q-TWiST analysis.
The median overall cost per patient was $14,413 (range, $1188-$39,598) for all patients and for limited disease and extensive disease was $18,234 (range, $1914-$39,598) and $13,177 (range, $1188-$32,798) respectively. The two major costs were hospitalisation (42%) and chemotherapy (18%). Radiotherapy accounted for 11% of all costs. The Q-TWiST analysis suggests that for patients with limited disease, quality-adjusted survival is similar to absolute survival.
The treatment of SCLC at our institution was expensive but the cost may be reduced by reduction in the duration of hospitalisation, the use of less expensive combination drug regimens, or the use of "true" outpatient chemotherapy. Despite intensive therapy, patients with limited disease maintained a reasonable quality of life.
确定治疗小细胞肺癌(SCLC)的成本,并评估这些患者的质量调整生存期。
回顾性分析。
西梅德医院,一家三级转诊机构。
1987年1月至1987年12月期间连续纳入的31例经组织学证实的SCLC患者样本。
分别为患者总体以及局限性疾病和广泛性疾病患者的检查、住院、化疗、放疗及随访成本。质量调整生存期基于Q-TWiST分析。
所有患者的人均中位总成本为14,413美元(范围:1188美元至39,598美元),局限性疾病患者为18,234美元(范围:1914美元至39,598美元),广泛性疾病患者为13,177美元(范围:1188美元至32,798美元)。两项主要成本为住院(42%)和化疗(18%)。放疗占所有成本的11%。Q-TWiST分析表明,对于局限性疾病患者,质量调整生存期与绝对生存期相似。
我们机构对SCLC的治疗成本高昂,但可通过缩短住院时间、使用成本较低的联合用药方案或采用“真正的”门诊化疗来降低成本。尽管进行了强化治疗,局限性疾病患者仍维持了合理的生活质量。