Bilous M, Milliken J, Mathijs J M
Department of Anatomical Pathology, Westmead Hospital, New South Wales, Australia.
Eur J Cancer. 1992;28A(6-7):1033-7. doi: 10.1016/0959-8049(92)90449-c.
The breast tumour distribution of epidermal growth factor receptor (EGFR) was studied in 193 patients with primary breast cancer by immunocytochemistry on frozen sections. EGFR was correlated (P = 0.0009) with growth fraction assessed by Ki-67, and negatively correlated with oestrogen receptor (ER, P = 0.0001) and progesterone receptor (PR, P = 0.0001) status. In 47 patients, in-situ hybridisation for EGFR mRNA showed good agreement with the immunocytochemically assessed EGFR protein. There were, however, several tumours in which EGFR mRNA could be detected in the absence of EGFR protein and there were differences between the ER and PR status of those tumours in which translation of EGFR mRNA was not seen. The cause of these differences is unclear, but these findings may represent a clue as to the differential control of breast cancer cell receptors.
通过对193例原发性乳腺癌患者的冰冻切片进行免疫细胞化学研究，分析了表皮生长因子受体（EGFR）在乳腺肿瘤中的分布情况。EGFR与通过Ki-67评估的生长分数相关（P = 0.0009），与雌激素受体（ER，P = 0.0001）和孕激素受体（PR，P = 0.0001）状态呈负相关。在47例患者中，EGFR mRNA的原位杂交结果与免疫细胞化学评估的EGFR蛋白结果具有良好的一致性。然而，有几例肿瘤在未检测到EGFR蛋白的情况下却能检测到EGFR mRNA，并且在那些未出现EGFR mRNA翻译的肿瘤中，ER和PR状态存在差异。这些差异的原因尚不清楚，但这些发现可能为乳腺癌细胞受体的差异调控提供线索。
