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茵栀黄注射液治疗小儿肝炎综合征

[Treatment of infantile hepatitis syndrome with injection of yin zhi huang].

作者信息

Dong Y S, Huang Z H, Wu L F

机构信息

Dept. of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Jan;12(1):26-7, 5-6.

PMID:1320965
Abstract

The infantile hepatitis syndrome is defined as a liver disease which occurs during the infantile period with the clinical manifestation of jaundice, hepatomegaly and hepatic dysfunction. The cause of disease is complex and the treatment is difficult. From March 1987 to June 1988, 55 patients (treatment group) were treated with injection of yin zhi huang, and 15 cases (control group) with injection of Inosine, vitamin C and glucose. The course of treatment lasted 15 days. At the beginning and the end of the treatment, serum bilirubin level, sALT level, duodenal juice bilirubin level, liver size and T cell subsets in peripheral blood had been detected separately. The results showed that among the treatment group, serum bilirubin level was significantly lower at the end of the treatment than that of the control group. The sALT, and hepatomegaly were also reduced or lessened, while the duodenal juice bilirubin level was increased. But there was no difference in T cell subsets between the two groups.

摘要

婴儿肝炎综合征是指发生于婴儿期,以黄疸、肝肿大及肝功能障碍为临床表现的肝脏疾病。病因复杂,治疗困难。1987年3月至1988年6月,55例患者(治疗组)采用茵栀黄注射液治疗,15例患者(对照组)采用肌苷、维生素C及葡萄糖注射液治疗。疗程为15天。分别于治疗开始时及结束时检测血清胆红素水平、谷丙转氨酶(sALT)水平、十二指肠液胆红素水平、肝脏大小及外周血T细胞亚群。结果显示,治疗组治疗结束时血清胆红素水平显著低于对照组。谷丙转氨酶及肝肿大也有所减轻,而十二指肠液胆红素水平升高。但两组T细胞亚群无差异。

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