抗过敏性药物的研究。5. 新型抗过敏物质3-(1H-四氮唑-5-基)色酮的合成。
Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances.
作者信息
Nohara A, Kuriki H, Saijo T, Sugihara H, Kanno M, Sanno Y
出版信息
J Med Chem. 1977 Jan;20(1):141-5. doi: 10.1021/jm00211a030.
PMID:13214
Abstract
A number of 3-(1H-tetrazol-5-yl)chromones were synthesized and found to have antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test. These compounds are active when administered orally in rats and of possible value for the treatment of asthma.
摘要
合成了一系列3-(1H-四唑-5-基)色酮，并发现它们在大鼠被动皮肤过敏反应(PCA)试验中具有抗过敏活性。这些化合物经大鼠口服给药时有活性，对哮喘治疗可能有价值。
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