普罗迪恩类化合物的阿片受体结合与镇痛特性之间的关系。
Relationships between opiate receptor binding and analgetic properties of prodine-type compounds.
作者信息
Klee W A, Iorio M A
出版信息
J Med Chem. 1977 Feb;20(2):309-10. doi: 10.1021/jm00212a026.
PMID:13219
Abstract
The receptor binding affinities of some diastereoisomeric prodine analgoues have been compared with their analgetic activities determined by the hot-plate test in mice. The close correlation found between these potencies indicates that the relative analgetic activities of the alpha/beta isomers are determined primarily by the appropriate association to the receptor sites.
摘要
已将一些非对映异构丙氧芬类似物的受体结合亲和力与其通过小鼠热板试验测定的镇痛活性进行了比较。这些效能之间发现的密切相关性表明，α/β异构体的相对镇痛活性主要由与受体位点的适当结合所决定。
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