Kahn J
Department of Medicine, University of California, San Francisco.
Semin Liver Dis. 1992 May;12(2):121-7. doi: 10.1055/s-2007-1007384.
Knowledge of the HIV life cycle helps to plan rational modalities directed against the virus. The complex nature of the life cycle of HIV presents multiple unique targets. HIV binding to the cellular receptor CD4, viral enzymatic targets, HIV activation, viral protein synthesis, and protein packaging are examples of the types of targets available to inhibit the life cycle of HIV. Patients, community groups, regulatory agencies, national research groups, and the private pharmaceutical companies have joined forces to work to a common goal, effective HIV therapies. RT inhibitors have provided the best therapeutic options, but other drugs are being developed at a rapid pace. New drugs are entering clinical investigation and will be more widely available at early signs of clinical and laboratory effectiveness.
了解HIV的生命周期有助于规划针对该病毒的合理治疗方案。HIV生命周期的复杂性提供了多个独特的靶点。HIV与细胞受体CD4的结合、病毒酶靶点、HIV激活、病毒蛋白合成以及蛋白包装等都是可用于抑制HIV生命周期的靶点类型。患者、社区团体、监管机构、国家研究团队以及私营制药公司已经联合起来，朝着一个共同目标努力，即研发有效的HIV治疗方法。逆转录酶抑制剂已经提供了最佳的治疗选择，但其他药物也在快速研发中。新药正在进入临床研究阶段，一旦出现临床和实验室有效性的早期迹象，就会更广泛地应用。
