Fini M E, Girard M T, Matsubara M
MGH/Harvard Cutaneous Biology Research Center, Massachusetts General Hospital, Boston.
Acta Ophthalmol Suppl (1985). 1992(202):26-33. doi: 10.1111/j.1755-3768.1992.tb02165.x.
We have documented changes in expression of collagenolytic/gelatinolytic enzymes of the matrix metalloproteinase family (MMP) in healing or ulcerating corneal wounds of rat or rabbit. Correlation of our findings with specific changes in the extracellular matrix of the repair tissue suggests two different roles for the enzymes, MMP-2 and MMP-9. MMP-2 is expressed in undamaged corneal stroma where it may degrade the occasional collagen molecule that becomes damaged. After corneal wounding, expression of this enzyme is increased and much of it appears in the active form. These changes persist for at least seven months, suggesting that MMP-2 is involved in the prolonged process of collagen remodelling in the stromal repair tissue. MMP-9 is expressed in the epithelial layer of repair tissue with a timing suggesting it might participate in controlling resynthesis of the basement membrane. MMP-9 also appears to be involved in degradation of the epithelial basement membrane that precedes corneal ulceration.
我们已经记录了大鼠或兔愈合或溃疡角膜伤口中基质金属蛋白酶家族（MMP）的胶原溶解/明胶溶解酶表达的变化。我们的研究结果与修复组织细胞外基质的特定变化之间的相关性表明，MMP-2和MMP-9这两种酶具有不同的作用。MMP-2在未受损的角膜基质中表达，在那里它可能降解偶尔受损的胶原分子。角膜受伤后，这种酶的表达增加，并且大部分以活性形式出现。这些变化至少持续七个月，表明MMP-2参与了基质修复组织中胶原重塑的长期过程。MMP-9在修复组织的上皮层中表达，其时间表明它可能参与控制基底膜的重新合成。MMP-9似乎也参与了角膜溃疡之前上皮基底膜的降解。
