Müller C A, Einsele H
Sektion Transplantationsimmunologie und Immunhämatologie, Abt. II, Med. Univ.-Klinik und Poliklinik, Tübingen, Federal Republic of Germany.
Ann Hematol. 1992 Jun;64 Suppl:A140-2. doi: 10.1007/BF01715368.
HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graft-versus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions.
通过高灵敏度聚合酶链反应（PCR）技术在骨髓移植（BMT）患者的血液、尿液和皮肤活检样本中诊断出的人巨细胞病毒（HCMV）感染，与外周血淋巴细胞的重建以及皮肤免疫组织学改变相关，以此评估病毒感染与免疫系统恢复之间的相互作用，以及与移植物抗宿主病（GVHD）的诱发或加重情况。在一项前瞻性研究中，63名患者中有73%在BMT后中位时间25天出现病毒血症。这些病例中只有44%同时出现较高频率的急性GVHD症状，随后发展为HCMB疾病。在皮肤方面，发现了类似的免疫组织学改变，以及在GVHD皮肤症状出现之前频繁发生的原发性局部HCMV感染，这表明抗HCMV免疫反应直接参与了GVHD相关器官病变的诱发过程。
