聚集蛋白与神经肌肉接头的组织
Agrin and the organization of the neuromuscular junction.
作者信息
Rupp F, Hoch W, Campanelli J T, Kreiner T, Scheller R H
机构信息
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305.
出版信息
Curr Opin Neurobiol. 1992 Feb;2(1):88-93. doi: 10.1016/0959-4388(92)90168-k.
PMID:1322209
Abstract
Agrin is a component of the synaptic extracellular matrix and may regulate the organization of acetylcholine receptors and other synaptic molecules in both synapse regeneration and development. Analyses of cDNAs encoding agrin define a number of structural domains, including regions of homology to laminin, Kazal protease inhibitors, and epidermal growth factor repeats.
摘要
聚集蛋白是突触细胞外基质的一个组成部分，在突触再生和发育过程中可能调节乙酰胆碱受体及其他突触分子的组织。对编码聚集蛋白的cDNA的分析确定了一些结构域，包括与层粘连蛋白、卡扎尔蛋白酶抑制剂及表皮生长因子重复序列同源的区域。
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