γ干扰素对牛乳头瘤病毒（BPV1）转化的细胞系细胞介导的细胞毒性敏感性的影响。
Effect of interferon gamma on the sensitivity of bovine-papilloma-virus(BPV1)-transformed cell lines to cell-mediated cytotoxicity.
作者信息
Laatikainen A, Schultz-Suhonen L, Mäntyjärvi R
机构信息
Department of Clinical Microbiology, University of Kuopio, Finland.
出版信息
Cancer Immunol Immunother. 1992;35(3):205-10. doi: 10.1007/BF01756189.
The effect of interferon gamma (IFN gamma) on the immunogenicity and immunosensitivity of mouse cell lines transformed by bovine papillomavirus type 1 (BPV1) DNA was examined in a syngeneic mouse model. The overnight incubation of BPV1-transformed cell lines with 100 IU/ml IFN gamma did not affect their ability to induce the generation of cytotoxic effector cells but it clearly increased their sensitivity to lysis by interleukin-2-induced lymphokine-activated killer (LAK) cells and by non-specific LAK-type effector cells induced by BPV-1-transformed cell lines. The treatment of two allogeneic lymphoid tumour cell lines, P815X2 and YAC-1, with IFN gamma either decreased or had no effect on their sensitivity to LAK-cell-mediated lysis.
在同基因小鼠模型中，研究了γ干扰素（IFNγ）对由1型牛乳头瘤病毒（BPV1）DNA转化的小鼠细胞系的免疫原性和免疫敏感性的影响。将BPV1转化的细胞系与100 IU/ml的IFNγ孵育过夜，并不影响它们诱导细胞毒性效应细胞生成的能力，但明显增加了它们对白细胞介素-2诱导的淋巴因子激活的杀伤细胞（LAK细胞）以及由BPV-1转化的细胞系诱导的非特异性LAK型效应细胞裂解的敏感性。用IFNγ处理两种异基因淋巴样肿瘤细胞系P815X2和YAC-1，要么降低了它们对LAK细胞介导裂解的敏感性，要么没有影响。
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