Yamada M, Yamada M, Richelson E
Mayo Foundation, Jacksonville, FL 32224.
Eur J Pharmacol. 1992 Jun 5;226(2):187-8. doi: 10.1016/0922-4106(92)90183-v.
We have demonstrated that the aminosteroid, U-73122 (1-(6-([17 beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino)hexyl)-1H-pyrrole- 2,5-dione) blocks agonist induced down-regulation of neurotensin receptors in murine neuroblastoma clone N1E-115 cells. U-73122 is known to inhibit polyphosphoinositide hydrolysis by affecting the coupling of GTP-binding proteins. Our results may indicate that GTP-binding proteins play a role in the mechanism of down-regulation of the neurotensin receptor.
我们已经证明，氨基甾体U-73122（1-(6-([17β-3-甲氧基雌甾-1,3,5(10)-三烯-17-基]氨基)己基)-1H-吡咯-2,5-二酮）可阻断激动剂诱导的小鼠神经母细胞瘤克隆N1E-115细胞中神经降压素受体的下调。已知U-73122通过影响GTP结合蛋白的偶联来抑制多磷酸肌醇水解。我们的结果可能表明，GTP结合蛋白在神经降压素受体下调机制中起作用。
