Effects of ouabain on contractile response to norepinephrine in isolated rat aorta.
作者信息
Moromizato H, Miyagi H, Nakayama M, Higuchi M, Sakanashi M
机构信息
Department of Pharmacology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
出版信息
Gen Pharmacol. 1992 Mar;23(2):279-83. doi: 10.1016/0306-3623(92)90024-e.
PMID:1322339
Abstract
- Inhibition of sodium(Na+), potassium(K+)-ATPase activity was dependent on the concentration of ouabain and inverse to the concentration of potassium ([K+]) in the reaction mixture. 2. Contractility of isolated rat aorta preparation in response to norepinephrine was augmented by ouabain and low [K+]. 3. Results suggest that inhibition of Na+,K(+)-ATPase activity will be correlated with augmentation of vascular contractility maybe through activation of Na(+)-calcium exchange system.
摘要
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