• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[格列本脲对大鼠离体灌注胰腺中胰高血糖素和胰岛素分泌的作用研究]

[Action of glibenclamide on glucagon and insulin secretions studied on isolated and perfused pancreas of the rat].

作者信息

Loubatières A L, Loubatières-Mariani M M, Chapal J, Blayac J P

出版信息

C R Seances Soc Biol Fil. 1975;169(6):1568-71.

PMID:132249
Abstract

Glibenclamide stimulates the insulin secretion by the isolated and perfused rat pancreas, but does not inhibit glucagon secretion when the perfusion liquid contains 1.5 g/I glucose. In the absence of glucose in the perfusion medium, glibenclamide stimulates both insulin and glucagon secretions.

摘要

格列本脲可刺激离体灌注大鼠胰腺分泌胰岛素，但当灌注液中葡萄糖含量为1.5g/L时，它并不抑制胰高血糖素的分泌。在灌注培养基中无葡萄糖的情况下，格列本脲可刺激胰岛素和胰高血糖素的分泌。

相似文献

1
[Action of glibenclamide on glucagon and insulin secretions studied on isolated and perfused pancreas of the rat].[格列本脲对大鼠离体灌注胰腺中胰高血糖素和胰岛素分泌的作用研究]
C R Seances Soc Biol Fil. 1975;169(6):1568-71.
2
[Adenosine triphosphate (ATP) and glucose. Action on insulin and glucagon secretion].[三磷酸腺苷（ATP）与葡萄糖。对胰岛素和胰高血糖素分泌的作用]
C R Seances Soc Biol Fil. 1976;170(4):833-6.
3
Effects of D-phenylalanine-derivative hypoglycemic agent A-4166 on pancreatic alpha- and beta-cells: comparative study with glibenclamide.
Pharmacology. 1995 Mar;50(3):175-81. doi: 10.1159/000139280.
4
[Effects of sodium DL lactate on secretion of insulin and glucagon. Study on the isolated perfused rat pancreas].[DL-乳酸钠对胰岛素和胰高血糖素分泌的影响。对离体灌注大鼠胰腺的研究]
C R Seances Soc Biol Fil. 1974;168(8-9):1038-44.
5
Glibenclamide stimulates and glucose inhibits glucagon release induced by calcium deprivation.格列本脲刺激而葡萄糖抑制钙缺乏诱导的胰高血糖素释放。
Diabetes. 1984 Jun;33(6):505-9. doi: 10.2337/diab.33.6.505.
6
Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas.葡萄糖/磺脲类药物相互作用对离体灌注大鼠胰腺胰岛素、胰高血糖素和生长抑素释放的影响。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5901-4. doi: 10.1073/pnas.76.11.5901.
7
[In vitro and in vivo effect of gold thioglucose on the insulin- and glucagon-secretion of the isolated perfused rat pancreas].[硫代葡萄糖金对离体灌注大鼠胰腺胰岛素和胰高血糖素分泌的体外和体内作用]
Biomed Biochim Acta. 1986;45(4):507-22.
8
[Correlation between lactate output and insulin secretion of the isolated perfused rat pancreas under the influence of high concentrations of phenformin].
C R Seances Soc Biol Fil. 1976;170(4):828-32.
9
Difference in calcium dependency of insulin, glucagon and somatostatin secretion in response to glibenclamide in perfused rat pancreas.灌注大鼠胰腺中胰岛素、胰高血糖素和生长抑素分泌对格列本脲反应的钙依赖性差异。
Diabetologia. 1982 Jun;22(6):475-9. doi: 10.1007/BF00282593.
10
Sulphonylurea (glubenclamide) enhances somatostatin and inhibits glucagon release induced by arginine.磺酰脲类（格列本脲）可增强生长抑素并抑制精氨酸诱导的胰高血糖素释放。
Acta Physiol Scand. 1980 Mar;108(3):231-3. doi: 10.1111/j.1748-1716.1980.tb06527.x.

引用本文的文献

1
Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas.葡萄糖/磺脲类药物相互作用对离体灌注大鼠胰腺胰岛素、胰高血糖素和生长抑素释放的影响。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5901-4. doi: 10.1073/pnas.76.11.5901.