二苯乙内酰脲对唾液分泌以及微粒体钙的积累和释放的影响。

Diphenylhydantoin effects on salivary secretion and microsomal calcium accumulation and release.

作者信息

Watson E L, Siegel I A

出版信息

Eur J Pharmacol. 1976 May;37(1):207-11. doi: 10.1016/0014-2999(76)90025-x.

Abstract

Diphenylhydantoin inhibited calcium uptake into dog submandibular microsomes at concentrations of 0.05 mM and greater but did not affect calcium release; mesantoin and hydroxyphenyl-phenylhydantoin were without effect. Diphenylhydantoin (20 mg/kg) given i.v. significantly reduced, and mesantoin slightly reduced secretion from submandibular and parotid glands, but hydroxyphenyl-phenylhydantoin was without effect. These data suggest that the reduced secretory volume produced by diphenylhydantoin may be related to its effect on transmembrane calcium movements.

摘要

苯妥英在浓度为0.05 mM及更高时可抑制钙摄入犬下颌下腺微粒体，但不影响钙释放；甲妥英和羟基苯基苯妥英则无此作用。静脉注射苯妥英（20 mg/kg）可显著减少，甲妥英可轻微减少下颌下腺和腮腺的分泌，但羟基苯基苯妥英无此作用。这些数据表明，苯妥英产生的分泌量减少可能与其对跨膜钙转运的影响有关。